Paraoxonase Polymorphisms and Platelet Activating Factor Acetylhydrolase Activity as a Genetic Risk Factors in Cerebral Atherosclerosis
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چکیده
منابع مشابه
A Brief Review of the Association between Genetic Polymorphisms of the Paraoxonase Family and Atherosclerosis
Atherosclerosis is known as an inflammatory disease that can affect any vessel in the body. The occurrence of atherosclerosis in heart vessels is called coronary artery disease (CAD). CAD is one of the most significant causes of morbidity and mortality in developed countries. Different genetic and environmental factors can cause cardiovascular diseases, such as age, weight, sex, and low high-de...
متن کاملPlatelet activating factor-acetylhydrolase (PAF-AH) activity and HDL levels, but not PAF-AH gene polymorphisms, are associated with successful aging in Sicilian octogenarians.
BACKGROUND AND AIMS Aging is associated with an increased risk of developing atherosclerosis. Subjects over 80 years of age without cardiovascular disease provide a model to investigate the protective factors increasing their resistance to atherosclerotic disease. Platelet-activating factor acetylhydrolase (PAF-AH) is an enzyme associated with low density lipoprotein (LDL) and high density lipo...
متن کاملAlterations of paraoxonase and platelet-activating factor acetylhydrolase activities in patients on peritoneal dialysis.
OBJECTIVE The more atherogenic lipid profile seen in peritoneal dialysis (PD) patients cannot fully explain the increased incidence of atherosclerosis in this population. Oxidative modification of low-density lipoproteins (LDL) is considered to play a central role in the atherogenic process, whereas high-density lipoprotein (HDL) protects LDL from oxidation. On the other hand, it has been sugge...
متن کاملAltered activities of anti-atherogenic enzymes LCAT, paraoxonase, and platelet-activating factor acetylhydrolase in atherosclerosis-susceptible mice.
We examined whether the putative anti-atherogenic enzymes LCAT, paraoxonase (PON), and platelet-activating factor acetylhydrolase (PAF-AH) are impaired in 8 week old atherosclerosis susceptible apolipoprotein E (apoE)(-/-) and LDL receptor (LDLr)(-/-) mice and whether plasma concentrations of bioactive oxidized phospholipids accumulate in plasma. ApoE(-/-) mice had reduced (28%) LCAT activity a...
متن کاملAltered Activities of Anti-atherogenic Enzymes Lecithin:cholesterol Acyltransferase, Paraoxonase and Platelet-activating Factor Acetylhydrolase in Atherosclerosis Susceptible Mice
We examined whether the putative anti-atherogenic enzymes lecithin:cholesterol acyltransferase (LCAT), paraoxonase 1 (PON) and platelet-activating factor acetylhydrolase (PAF-AH) are impaired in 8 week old atherosclerosis susceptible Apoe-/and Ldlr-/mice and whether plasma concentrations of bioactive oxidized phospholipids accumulate in plasma. Apoe-/mice had reduced (28%) LCAT activity and ele...
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